Sanopal Forte

SANOPAL is an innovative oral solution from Austria that contains the globally unique combination of active ingredients known as A5H, consisting of alpha-ketoglutarate and 5-hydroxymethylfurfural. Developed to the highest quality standards, SANOPAL represents modern product innovation.

Developed & manufactured in Austria

The patented active ingredient combination A5H, consisting of AKG and 5-HMF, from SANOPAL FORTE

Building on years of research and development, SANOPAL FORTE combines alpha-ketoglutarate (AKG) and 5-HMF (5-hydroxymethylfurfural) in a formulation that is unique worldwide. This exclusive combination forms the basis of SANOPAL FORTE and sets it apart from conventional formulations.

The Science Behind AKG & 5-HMF

Alpha-ketoglutarate (AKG) is a key intermediate in the citric acid cycle, a fundamental metabolic pathway for converting nutrients into energy (ATP). In addition to its central role in energy production, AKG acts as a metabolic regulator with antioxidant and anti-inflammatory properties. It supports the regulation of cellular antioxidant mechanisms, modulates inflammatory processes, and studies show that AKG supplementation can improve mitochondrial function and slow biological aging.1,2

5-Hydroxymethylfurfural (5-HMF) improves the oxygen affinity of hemoglobin and thereby contributes to improved oxygen supply in the blood, particularly under hypoxic conditions. In addition to these effects, antioxidant properties have also been described, including the scavenging of free radicals and the reduction of oxidative cell damage. Studies also suggest that 5-HMF may influence inflammatory processes, cellular signaling pathways, and cell proliferation.3,4

Hand pours Sanopal Forte sachet into a glass of water – easy daily intake of the Active Cell Cure for extraordinary demands such as burnout, Long COVID, and post-traumatic stress.

Water, sugar, alpha-ketoglutaric acid, 5-hydroxymethylfurfural, and magnesium chloride. Acidity regulators: sodium hydroxide, potassium hydroxide.

SANOPAL FORTE contains A5H – a patented combination of active ingredients consisting of AKG (alpha-ketoglutarate) and 5-HMF (5-hydroxymethylfurfural).

1 double sachet contains 2.4 g of A-KGS and 0.24 g of 5-HMF.

Calories 856 kJ / 200 kcal
Protein 0 g
Carbohydrates 37 g
Sugar 37 g
Fat 0 g
Saturated fatty acids 0 g
Salt 3,13 g
Potassium 1758 mg 1
Magnesium 65,7 mg 2

¹ Equivalent to 87.9% of the NRV (Nutrient Reference Value)
² Equivalent to 17.5% of the NRV (Nutrient Reference Value)

Information for people with diabetes: 1 double sachet contains 12 g of carbohydrates. This corresponds to 1 bread unit.

How To Use SANOPAL FORTE

Once prepared, the beverage should be consumed within 24 hours.

Open 1 double sachet along the perforation, dissolve the contents of both parts in at least 250 ml of water, mix and drink. The recommended time to take it is 30 minutes before or 120 minutes after a meal. It is not recommended to take it after 6:00 p.m.
Important Note

May only be used under medical supervision! Keep out of reach of children and store refrigerated. Food for special medical purposes (balanced diet).

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Challenges of the Modern Age

Disruptions in cellular energy production and mitochondrial function are increasingly recognized as a common pathophysiological basis for numerous diseases. These include, among others, Long COVID⁵, chronic fatigue syndrome (CFS)⁶, various neurodegenerative⁷ and cardiovascular⁸ diseases, as well as viral infections⁹. Against this backdrop, improving cellular energy supply is increasingly becoming the focus of research as a potential therapeutic approach.¹⁰

Studies on Our Active Ingredient Combination

The combination of alpha-ketoglutarate (AKG) and 5-hydroxymethylfurfural (5-HMF) has proven particularly promising in the context of preoperative preparation and has been associated with a shorter hospital stay and a reduction in postoperative complications.11

Menschen wie Sie vertrauen auf SANOPAL FORTE

Von täglicher Gesundheitsvorsorge bis zur Unterstützung bei starker Erschöpfung.

FORTE

Burnout & Erschöpfung

Leistungsdruck und Verantwortung

FORTE

Chronische Müdigkeit & Fatigue

Fatigue, ME/CFS oder Long-COVID

FORTE

Vor und nach Operationen

Regeneration nach einer Operation

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  1. Xia Y, Wang H, Meng Q. Context-dependent roles of alpha-ketoglutarate in brain disorders: molecular mechanisms and translational opportunities. J Transl Genet Genomics. 2026;10(2):164-183. doi:10.20517/jtgg.2026.18
  2. Liu S, He L, Yao K. The Antioxidative Function of Alpha-Ketoglutarate and Its Applications. BioMed Res Int. 2018;2018:3408467. doi:10.1155/2018/3408467
  3. Pagare PP, McGinn M, Ghatge MS, et al. The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications. doi:10.1002/med.22062
  4. Woyke S, Mair N, Ortner A, et al. Dose- and Sex-Dependent Changes in Hemoglobin Oxygen Affinity by the Micronutrient 5-Hydroxymethylfurfural and α-Ketoglutaric Acid. Nutrients. 2021;13(10):3448. doi:10.3390/nu13103448
  5. Macnaughtan J, Chau KY, Brennan E, et al. Mitochondrial function is impaired in long COVID patients. Ann Med. 2025;57(1):2528167. doi:10.1080/07853890.2025.2528167
  6. Missailidis D, Annesley SJ, Allan CY, et al. An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients. Int J Mol Sci. 2020;21(3):1074. doi:10.3390/ijms21031074
  7. Filosto M, Scarpelli M, Cotelli MS, et al. The role of mitochondria in neurodegenerative diseases. J Neurol. 2011;258(10):1763-1774. doi:10.1007/s00415-011-6104-z
  8. Murphy E, Ardehali H, Balaban RS, et al. AHA Position Paper on Mitochondrial Function, Biology and Role in Disease. Circ Res. 2016;118(12):1960-1991. doi:10.1161/RES.0000000000000104
  9. Li X, Wu K, Zeng S, et al. Viral Infection Modulates Mitochondrial Function. Int J Mol Sci. 2021;22(8):4260. doi:10.3390/ijms22084260
  10. Sorrentino V, Menzies KJ, Auwerx J. Repairing Mitochondrial Dysfunction in Disease. Annu Rev Pharmacol Toxicol. 2018;58(Volume 58, 2018):353-389. doi:10.1146/annurev-pharmtox-010716-104908
  11. Matzi V, Lindenmann J, Muench A, et al. The impact of preoperative micronutrient supplementation in lung surgery. A prospective randomized trial of oral supplementation of combined alpha-ketoglutaric acid and 5-hydroxymethylfurfural. Eur J Cardio-Thorac Surg Off J Eur Assoc Cardio-Thorac Surg. 2007;32(5):776-782. doi:10.1016/j.ejcts.2007.07.016