{"id":2331,"date":"2026-06-02T17:09:33","date_gmt":"2026-06-02T15:09:33","guid":{"rendered":"https:\/\/sanopal.health\/active-ingredient\/"},"modified":"2026-08-12T09:21:22","modified_gmt":"2026-08-12T07:21:22","slug":"active-ingredient","status":"publish","type":"page","link":"https:\/\/sanopal.health\/en\/active-ingredient\/","title":{"rendered":"Active ingredient"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2331\" class=\"elementor elementor-2331 elementor-757\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ad8b6d6 e-con-full e-flex e-con e-parent\" data-id=\"ad8b6d6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-37b22e1 e-con-full e-flex e-con e-child\" data-id=\"37b22e1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f620bed elementor-align-center elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"f620bed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-long-arrow-alt-right\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M313.941 216H12c-6.627 0-12 5.373-12 12v56c0 6.627 5.373 12 12 12h301.941v46.059c0 21.382 25.851 32.09 40.971 16.971l86.059-86.059c9.373-9.373 9.373-24.569 0-33.941l-86.059-86.059c-15.119-15.119-40.971-4.411-40.971 16.971V216z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">The science behind it<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e42377b elementor-widget elementor-widget-heading\" data-id=\"e42377b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">The A5H active ingredient combination<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b04eb6 elementor-widget elementor-widget-text-editor\" data-id=\"7b04eb6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Building on years of research and development, SANOPAL combines alpha-ketoglutarate (AKG) and 5-HMF (5-hydroxymethylfurfural) in a formulation that is unique worldwide.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1abe065 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile e-flex e-con-boxed e-con e-parent\" data-id=\"1abe065\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3f12744 e-con-full e-flex e-con e-child\" data-id=\"3f12744\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-1ada715 e-con-full e-flex e-con e-child\" data-id=\"1ada715\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-50abc89 e-con-full liftup e-flex e-con e-child\" data-id=\"50abc89\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-db561c2 elementor-widget elementor-widget-heading\" data-id=\"db561c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Conversion of nutrients into energy (ATP)<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-31a95b1 e-con-full liftup e-flex e-con e-child\" data-id=\"31a95b1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d221cd1 elementor-widget elementor-widget-heading\" data-id=\"d221cd1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Antioxidant and anti-inflammatory properties<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1d49bde e-con-full liftup e-flex e-con e-child\" data-id=\"1d49bde\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f4a786c elementor-widget elementor-widget-heading\" data-id=\"f4a786c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Reduction of oxidative cell damage<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1e65908 e-con-full liftup e-flex e-con e-child\" data-id=\"1e65908\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d101aea elementor-widget elementor-widget-heading\" data-id=\"d101aea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Oral solution for fast and efficient utilization of active ingredients.<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fdbe40a e-flex e-con-boxed e-con e-parent\" data-id=\"fdbe40a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-51183a5 e-con-full e-flex e-con e-child\" data-id=\"51183a5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-35e6afc elementor-widget elementor-widget-heading\" data-id=\"35e6afc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Alpha-Ketoglutarate<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3661ee3 elementor-widget elementor-widget-text-editor\" data-id=\"3661ee3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Alpha-ketoglutarate (AKG) is a key intermediate in the citric acid cycle, a fundamental metabolic pathway for converting nutrients into energy (ATP). In addition to its central role in energy production, AKG acts as a metabolic regulator with antioxidant and anti-inflammatory properties. It supports the regulation of cellular antioxidant mechanisms, modulates inflammatory processes, and studies show that AKG supplementation can improve mitochondrial function and slow biological aging.<sup>1,2<\/sup>  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3388763 e-con-full e-flex e-con e-child\" data-id=\"3388763\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-abb304e elementor-widget elementor-widget-image\" data-id=\"abb304e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/sanopal.health\/wp-content\/uploads\/2026\/07\/a5h-Stempel-1024x1024.png\" class=\"attachment-large size-large wp-image-2332\" alt=\"Seal of the patented A5H active ingredient combination of alpha-ketoglutarate and 5-hydroxymethylfurfural \u2013 basic research from Austria, Sanopal Active Cell Cure\" srcset=\"https:\/\/sanopal.health\/wp-content\/uploads\/2026\/07\/a5h-Stempel-1024x1024.png 1024w, https:\/\/sanopal.health\/wp-content\/uploads\/2026\/07\/a5h-Stempel-300x300.png 300w, https:\/\/sanopal.health\/wp-content\/uploads\/2026\/07\/a5h-Stempel-150x150.png 150w, https:\/\/sanopal.health\/wp-content\/uploads\/2026\/07\/a5h-Stempel-768x769.png 768w, https:\/\/sanopal.health\/wp-content\/uploads\/2026\/07\/a5h-Stempel-1534x1536.png 1534w, https:\/\/sanopal.health\/wp-content\/uploads\/2026\/07\/a5h-Stempel-2046x2048.png 2046w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-547df9d e-flex e-con-boxed e-con e-parent\" data-id=\"547df9d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-760af08 e-con-full e-flex e-con e-child\" data-id=\"760af08\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0608efc elementor-widget elementor-widget-heading\" data-id=\"0608efc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5-Hydroxymethylfurfural<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ffed23a elementor-widget elementor-widget-text-editor\" data-id=\"ffed23a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>5-Hydroxymethylfurfural (5-HMF) improves the oxygen affinity of hemoglobin and thereby contributes to improved oxygen supply in the blood, particularly under hypoxic conditions. In addition to these effects, antioxidant properties have also been described, including the scavenging of free radicals and the reduction of oxidative cell damage. Studies also suggest that 5-HMF may influence inflammatory processes, cellular signaling pathways, and cell proliferation.3,4  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-289b894 e-con-full e-flex e-con e-parent\" data-id=\"289b894\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6ce0713 elementor-widget elementor-widget-shortcode\" data-id=\"6ce0713\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\t\t<div data-elementor-type=\"container\" data-elementor-id=\"2282\" class=\"elementor elementor-2282 elementor-893 elementor-893\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1b1662a4 e-flex e-con-boxed e-con e-parent\" data-id=\"1b1662a4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3543b602 e-con-full e-flex e-con e-child\" data-id=\"3543b602\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6047acc7 elementor-widget elementor-widget-heading\" data-id=\"6047acc7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Ready for more energy?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-47f6093e elementor-widget elementor-widget-text-editor\" data-id=\"47f6093e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>You will be redirected to our shopping partner, who will handle the secure transaction.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-df44ca3 e-con-full e-flex e-con e-child\" data-id=\"df44ca3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4ec4ae7b elementor-widget elementor-widget-button\" data-id=\"4ec4ae7b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/sanopal.health\/shop\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Go to the Online Store \u2192<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b9606b2 elementor-widget elementor-widget-button\" data-id=\"3b9606b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/kampagne.doc.green\/sanopal-w-at#\/\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Click &amp; Collect at Your Pharmacy<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-26584bc7 elementor-widget elementor-widget-text-editor\" data-id=\"26584bc7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Order SANOPAL FORTE or BASIC &#8211; delivered right to your door or via Click &amp; Collect.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9ab8df8 e-flex e-con-boxed e-con e-parent\" data-id=\"9ab8df8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-610a67b e-con-full e-flex e-con e-child\" data-id=\"610a67b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c1fa811 elementor-widget elementor-widget-text-editor\" data-id=\"c1fa811\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ol><li>Xia Y, Wang H, Meng Q. Context-dependent roles of alpha-ketoglutarate in brain disorders: molecular mechanisms and translational opportunities. <em>J Transl Genet Genomics<\/em>. 2026;10(2):164-183. doi:10.20517\/jtgg.2026.18  <\/li><li>Liu S, He L, Yao K. The Antioxidative Function of Alpha-Ketoglutarate and Its Applications. <em>BioMed Res Int<\/em>. 2018;2018:3408467. doi:10.1155\/2018\/3408467<\/li><li>Pagare PP, McGinn M, Ghatge MS, et al. The antisickling agent, 5\u2010hydroxymethyl\u20102\u2010furfural: Other potential pharmacological applications. doi:10.1002\/med.22062  <\/li><li>Woyke S, Mair N, Ortner A, et al. Dose- and Sex-Dependent Changes in Hemoglobin Oxygen Affinity by the Micronutrient 5-Hydroxymethylfurfural and \u03b1-Ketoglutaric Acid. <em>Nutrients<\/em>. 2021;13(10):3448. doi:10.3390\/nu13103448 <\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>The science behind it The A5H active ingredient combination Building on years of research and development, SANOPAL combines alpha-ketoglutarate (AKG) and 5-HMF (5-hydroxymethylfurfural) in a formulation that is unique worldwide. Conversion of nutrients into energy (ATP) Antioxidant and anti-inflammatory properties Reduction of oxidative cell damage Oral solution for fast and efficient utilization of active ingredients. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2269,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-2331","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/sanopal.health\/en\/wp-json\/wp\/v2\/pages\/2331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sanopal.health\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sanopal.health\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sanopal.health\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sanopal.health\/en\/wp-json\/wp\/v2\/comments?post=2331"}],"version-history":[{"count":1,"href":"https:\/\/sanopal.health\/en\/wp-json\/wp\/v2\/pages\/2331\/revisions"}],"predecessor-version":[{"id":2333,"href":"https:\/\/sanopal.health\/en\/wp-json\/wp\/v2\/pages\/2331\/revisions\/2333"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sanopal.health\/en\/wp-json\/wp\/v2\/media\/2269"}],"wp:attachment":[{"href":"https:\/\/sanopal.health\/en\/wp-json\/wp\/v2\/media?parent=2331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}